OK, I admit it... it was me... that rumbling noise in the distance...
I was getting frustrated with a quest boss (whom most of you probably know, but who will remain un-spoilered here for everyone else's benefit). I had met him for the first time, we had our angry conversation and then the inevitable showdown... and I kept dying. Either he would kill me directly, or his circling minions would beat him to the punch. No strategy I tried was working; whichever way I turned my gun, there was an enemy behind me or outflanking me (these guys didn't flunk flank, either), and down I would go.
Finally, at the save point just before the confrontation, I turned to my companion and commanded a trade. Unwisely, my enemy had left a Fat Man in a nearby room, and I had picked it up, giving it to my partner to tote. "Surely," the villain must have thought, "surely no one would be fool enough to use this against me in my own indoor hideout."
Well, I was fool enough.
Too bad I underestimated the blast radius.
The story ends well; the next time around, I found the combination of chems, food, weapons, and technique (and probably dumb luck) to get me through the firefight alive. I grant you it also took a Nuka Grenade, which almost killed me too, but hey, a cheap victory is better than no victory.
So, who else in this esteemed forum has also fired a thermonuclear weapon inside an enclosed building (or done something equally as foolhardy)?
Come, let us regale one another with tales of our own video stupidity!!!!