Polymorphism in Tamriel is a...nasty affair. It tends to be associated with dangerous hedge-magics, and are less "I'mma turn into a bear" and more becoming some twisted abomination like Hagravens. Then there's the Wild Hunt, and that's infinitely more disastrous for everyone and everything remotely close to one. But as far as limitations go...there's nothing I'm aware that magic couldn't theoretically accomplish, in a sense. Now its worth mentioning that most Mages in the entire setting will never ever see that kind of stuff. Even in large group, extraordinary feats are a bit of a rarity, and the likes of Shalidor, Mannimarco, the Psijiics are going to be extremely rare.
That said, there's nothing in Tamriel that can't be considered magical to begin with. Its not spellcraft, but things like Pelinal running amok, Hrol's hill fetish, everything about the Dwemer, godly interventions are all usually magical in nature.
Not something we actually have any exposition on, aside from Telvanni's habit of self-experimentation to increase their own lifespan (which could be taken as blood magic in other settings, depending on the definition), nothing is ever cited as ever being different then normal magics, including things like blood sacrifices. Doesn't really seem to stand out as anything particularly special. I have a few headcanons regarding it, but that's really all they are.