Oh god, my first one was the one caged up at Evergreen. I took out the guys patrolling at the far end then tried to free the slaves, that didn't work and while I was trying to work out why they weren't running for freedom a raider spotted me and a firefight broke out, I chewed my way towards the main building when one of them ran up to the generator powering those big gates and blew it up, seemingly on purpose (maybe the AI does it if they're attacked?)

Next thing I know it's a three way fight between me, the raiders and this giant green hellish beast thing which seems to just eat the bullets I'm firing at it. In the end I was wedged in behind a container crying like a sissy and desperately low on ammo when the damn thing went down.
Not fun. I was a very low level, it was my first playthrough and I had no experience with super mutants, much less the damned behemoths.