Some more information might help.
* Is this a new install?
* Are you currently or have you in the past used mods for your Skyrim game?
* If it is a Steam install are you running Steam as an administrator? I've personally not encounters this problem (so it may be a thing of the past), but I've read others saying that depending on which OS they have, that they have needed to run Steam as an administrator to keep games from crashing on start up.
* I'm sure you have already checked, but I have to ask anyway. Did you make sure your computer meets the minimum suggested System requirements?
If answers are too long in coming this is listed on Bethesda's general info page:
GENERAL INFO: BETHESDA SOFTWORKS LLC, 1370 Piccard Drive Suite 120, Rockville MD 20850, (301) 926-8300