I'm planning on restarting my character that I beat the MQ with. As to a 'survival mode' build, well.. I'm sure she'll become effective eventually anyway. It's kind of a nice idea starting out weaker in a mode like that, anyway.
I wonder how the Deathclaw encounter in the start will look with that, though. We'll have Power Armor and a minigun and do more damage to it, but.. it'll kill us in probably one hit at the level we're at anyway.