I have always liked so-called "unarmed" combat in FO, but in FO4 can anyone say with certainty that melee specific perks also work with fist weapons? (Aside from Big Leagues, that is obvious). They just have not implemented anything very interesting in regards to unarmed weapons in FO4. I really liked the steel knux from the Pitt and Plunkett's Valid Points, as well as every single unarmed weapon in NV, but these weaps in FO4 leave something to be desired.
Regardless, I prefer unarmed anyway because the Paralyzing Palm perk, or the final rank of Iron Fist in FO4, is a pretty powerful thing, plus I generally like the weapons better than "melee" weapons.
Never bring a knife to a gunfight... but BGS have tweaked the rules here a little bit to make it more fair when you specialize with perks and whatnot. I will definitely be more interested in melee and unarmed when the survival mode update comes out and ammo has weight. I don't think combat will be straight up tipped on its axis, but I do want something strong to fall back on just to conserve ammo.
The melee weapons do always have a good reason for existing in the FO universe--improvised tools and cobbled together salvage, high tech stuff, old pre-war weaps from civilians or military.