I had been having the same crashing issue that many others have been having with the SE of Skyrim. After about a week of frustration I tried fiddling with all the settings and whatnot that I could, and I tried disabling all of my mods to no avail. I then deleted every single one and started a new game; same crash issue. However, when I was in the mod menu I checked my load order and there was a single mod in there, despite my having removed all of my mods. The mods' name and file size were still visible, but I couldn't access it's page in the menu, and its icon was nothing more than a white square. Once I removed this apparently knackered mod from my load order, the game worked completely fine, both in modded and vanilla playthroughs.
This may not help everyone, as I saw that some people are having the same issue with vanilla games where there would never have been any mods installed, but hopefully it will help some