I'm a little late to the party, I just started playing again a few days ago. I have a new rig with win 10 so a bit of a learning curve.
First, Does the in-game Beth mod option isolate the mods from the vanilla game like MO? I.E. Can I add and remove mods without risk of corrupting the vanilla game/overwrites/ect? Just saying you can remove mods and load your previous game is a bit ambiguous..
Second, I'm having an issue setting up MO on this machine, long story short I am stuck where it asks you to select the game, none are auto detected and I cant seem to manually select it.
More detail here -
forums. nexusmods. com /index.php?/topic/5072245-initial-set-up-mod-organizer-detectingselecting-skyrim/