I guess that all depends on what you would consider a "must do" or "must have". For me, my "must have" in those side quests was The Gift quest. The ability to turn my spouse into a vampire that doesn't have any of the bat-face changes that make the newer vampires so butt ugly. That's the only way in the game to do that, so for me that was a "must have". As for the other side quests I can't really say because I haven't finished more than 2 of them, but the ones I've heard of so far seem pretty skippable to me.