No, not if the goal is just increasing your characters level. Both setlevel and advlevel work just fine for that, and the game won't know the difference. If your goal is also to rack up a bunch of XP, perk points, and fake skill and stat gains to approximate what you would be at that higher level then other methods might be the better choice, simply because all that can get a bit complicated if done through the console.
Note - adding items is usually not a problem unless it involves a quest item that's normally obtained through dialog with an NPC, because there's usually a player inventory check for that item that goes along with the quest. Adding those items early or out of order can nerf the quest and the NPCs dialog. Most other quest item "pickups" from a location involve a scripted "item dispenser" object that you have to physically activate to trigger the "item obtained" quest objective, so the quest won't know if you add 50 of those through the console because it's not meant to care. One example is Dawnbreaker.. only clicking on the pedestal at that location will advance the quest. All other regular and common items are safe to add at any time.