How far in are you? I'm at 68 hours and still haven't started mr house.
Completed one play through in 40 some hours, following the Legion quests, that was my "get a grasp of the game" file. Also had a character who had moved halfway through House/Yes Man's quests, but killed that character, am now 15 hours 30 mins into a second playthrough, haven't started the main quest at all, outside of Victor in Goodsprings.
I've encountered buildings with interiors that are much larger than the exteriors (design, not software/hardware), areas where dropping items are funked, some areas of lag (most fixed by installing to harddrive) and two rare and non-repeatable freezes.