For example, the book says: you walk up to an old man in his 50's. his thin body was covered merely by a few pieces of rag. Sorrow and fear can be felt from his eyes, yet his warm smile reminds you of hope. While looking at you, he was busy catching lice beneath his clothes, and the itchiness made him constantly scratch his body, leaving many rashes and ulcers.
Now, how are you going to represent this thing to the player using modern day gaming technology? We only have a generic body mesh, some pixelated texture, and a few necessary animations for each NPC, so there's no way we can convey the same amount of information using graphics alone.
Maybe, we can have a "observe" button in the game, and when used on objects it displays some kind of description of the object? I know it's primitive and might sound stupid, but as far as I know, no other games have attempted this. Maybe it'll have a positive effect over all