i'm pretty sure this game is gonna feel weird and noobish.
On a serious note, I think it's safe to assume that what this really translates to is: "It looks so different, and I'm going to feel like a weird noob playing it."
Some people are afraid of that, and that's fine I guess. I embrace that feeling. I love being dropped into the middle of something totally foreign and seeing myself gain my bearings and adapt over time. I love when I go into to something with next to no experience, and really have a chance to explore the fundamentals until I'm competent enough to use them all to my advantage and create my own methods and playstyle.
Borderlands was the first FPS that I had committed myself to since 007 on N64, and I've never played a Splash Damage game. But rather than being overwhelmed by that, I have a great desire to become great at the game and really take full advantage of what looks to be an incredibly awesome new world and experience. I don't care if I svck at first or even if people bust my balls.