Heading to the new DLC I am only going to take the Reinforced Sierra Madre Armor and a shishkebab. I love the shishkebab, with some decent crit and pyromaniac it's probably the strongest weapon by weight, not including the alien blaster until we find a renewable ammo source. I'd take a few weapon repair kits and my weightless AID items. I would try out new gear as I go through the DLC while also having decent gear to fall back on and having a ton of inventory space to haul as much loot back as possible.
actually the "ballistic fist" is pretty good too. i have my unarmed skill maxed out, and i'm getting 113 dps/105 dam. i'll prob just take that in, along with a long range weapon, and maybe the 12.7mm smg (333dps), and some repair items. i actually enjoy being "god-like" in video games(atleast after 200+ hrs of gameplay), unlike some of these folks.