I think it would be really cool if they locks that we can put on lockers,desk,containers,etc. If we had this we could have multiple homes where we could safely put our stuff in. Because in FO3 I got tired of the one house and there few others that were semi-reliable.
I hope the casinos have safe lockers where I can put my suits of armor and misc., and stuff like that ( I know that the "Casinop greeter" takes your weapons to a safe); because with my Blackjack skill those chips are going to get heavy.