I've agreed before and i will again so here's my copy-paste from the recommend a location thread(included a quote from CBManson):
I posted this before, but figured I should say it here; Central Texas.
Central Texas boasts the largest U.S. Army base with several cities around it. That being said, there is still plenty of areas that are open fields. The amount of cattle in the area would make for a great Brahmin (or another new cattle like animal) trade area.
Also, considering the fact that it is the largest military base, there could be a new faction Or perhaps the Enclave? They would fit right in at this area, considering their love of abandoned armed forces bases. Further more, considering the amount of hospitals in the area, there could be a big quest involving them. There are four, one on the base, one near the base, and two on the other side of town. Recently, the largest hospital took over the other two that are off base, but they still function as separates. Anyways, I felt it as a good idea because of the base itself.
The BoS (or again, a new faction) could use the hospitals as bases. I would also like to see a civil war between the smoothskins and the Ghouls. That would give the PC a great chance to choose sides. And maybe give the PC a way to become a Ghoul? That would be fun. My good character, Katrina, let the Ghouls into Tenpenny Tower and over all, never killed anyone other than a hostile feral. My evil character, Hoenheim, however is a Ghoul exterminator. I haven't gotten him to Underworld yet, as I just started him but when I do, I will clean the place out.
Sorry for the stray from the topic there. But anyways, what do you guys think?
Personally, being from Belton, I think that would be really cool to explore where I've lived my entire life. They could include one of the lakes too as they're mainly owned by Ft. Hood.(well belton lake at least)