That will cost you a butt-load of magicka to cast though, why not drain health 20 pts for 5 seconds?
Because the enemy will get all his health back after 5 seconds, if he had less than 20 health during then fight he will die else he would take no damage. Drain health temporary removes health and return it then the spells times out. this is why drain health 100 for 1 second is so powerful. Drain health 20 for 5 seconds will only have an effect if you cast spell then does other attacks and bring enemy health down to 20.
You might mix it with absorb health who takes health from enemy and gives to you. Absorb skill and attributes works like drain. absorb strength 20 in 5 seconds will do a drain strength 20 on enemy and fortify strength 20 on you. However absorb health, magic or fatigue works like damage health, magic or fatigue on enemy and restore health, magic or fatigue on you. If you are at full health the healing effect has no value but enemy does normal damage. Absorb health don't work on bows but is extremely powerful on melee weapons as it keep your health topped.