If you really want a brute character you really need to go with big guns imho. The character I beat all the DLC except for broken steel (Before I accidentally erased him) was a walking tank of destruction. 85 DR, 80 rad resistance, and a little over 500hp.
DR is your defense rating. The number is the percent of damage it protects from. With a DR of 50 a 80 damage strike would do 40 damage as 50% or half of the damage is blocked. With 85 DR attacks only do 15% of their normal damage.
How to get 85 DR
Spoiler Take the toughness and cyborg perks for 20 DR total, finish the wasteland survival guide while using the tough (strength and endurance) answers to moira's questions for 6 DR, get the perk from the Pitt DLC, get barkskin from the oasis quest, and then get the superior defender perk to round it out. Then also wear the winterized T51B. suit+helmet=55DR, and the armor has such a crazy high armor health rating that it never needs repair because it never wears down enough to be noticable.
My highly successful build looked like this:
S. 8
P. 6
E. 9
C. 1
I. 9
A. 1
L. 6
You can get 10 endurance with the bobblehead, and 10 strength from the bobble head and
Spoiler The ant might perk from the Those! quest
You do not really need charisma, and all agility does for you is add 2 A.P. per point, and give access to perks you do not need. Big guns work better outside of VATS so you don't really need the AP
Tag big guns, repair, and then choose a third skill of either Explosives, unarmed, melee, lockpicking, or science.
It works awesome and I think you would love it.