They should definitely have a FO take place in the Southern States. Louisiana, Florida, Alabama, etc. would be interesting since they're right there up against the Gulf Coast. (Not really Alabama, but they've got Mobile that's right there at the coast. It would be nice to see a side of a large body of water again.

http://www.gamesas.com/index.php?/topic/1155916-official-fallout-4-location-suggestions-3/