Quicksaves seem slightly more likely to go corrupt, and if you use them extensively that can throw you back quite a way since the quicksave overwrites previous quicksaves.
Streamline and Auto-Save and Time both allow you to re-map the quicksave key to use their quicksave alternatives which cycle through a series of quicksaves and alleviate the overwriting problem.
I'm sort of a saveaholic so I'm using Streamsave, quicksaves and also lots of hard saves.
Its also rather hit and miss.... Some folks can overwrite files and never have a problem. Others (myself included...) overwrite ONCE, and the file is toast. I have no clue what that is all about, or what contributing factors there are. I just chalk it up to a quirk of the game, and live with it. (and make new saves a lot.....)
Hm, wonder if it is connected to operating systems or something. Anyway, after thousands of hours playing Morrowind/Oblivion and tens of thousands quicksaves/quickloads I've never had a single issue. Should count as a pretty extensive test run of quicksaves/quickloads by now.

Not that I'm recommending it - just reporting my own experiences with them.