What platform?
I play on the 360 and the expansion disc is not one time use. I installed it on our previous system, which died...so we got a new one and I installed it easily on the new one. That's sort of the point of the hard disc
Xbox 360
So it's safe to get it used?
In the item's description on Amazon, it says:
"Includes manual, cover art, and case. Full game is included,
but bonus downloadable content may have already been redeemed. Cleaning and repair was done as required. Game data from previous use may be present, but can be overwritten or deleted. "