hmm.. so I don't need to worry about cleaning saves, and uhh something to do with references that I've heard people talk about when doing with new mods (cleaning references was it?). Sorry if that is complete jargon, but I sware I've heard these things mentioned before. Either way I think I'll start devising a cool telvanni house somewhere : D (yes Im very excited)
You only need to clean a save after you update a mod that had already been loaded in your game when the save was made. If you want to add a new plugin you don't need to worry about it.
However, you shouldn't update mods "on the fly" because that can easily cause doubling of object references (you can do it, just be sure to keep a backup save in case something goes wrong). If you want to update or improve your mod, it is safest to first unload it from your game and re-save your save game, and
then update the mod.