Thanks to anybody with the knowledge.

[X] Fallout3.esm
[X] Anchorage.esm
[X] ThePitt.esm
[X] BrokenSteel.esm
[X] PointLookout.esm
[X] Zeta.esm
[X] Unofficial Fallout 3 Patch.esm
[X] CRAFT.esm
[X] CALIBR.esm
[X] xCALIBR.esm
[X] Project Beauty.esm
[X] SuperJump1.5x.esm
[X] The Bunker.esm
[X] COMM.esm
[X] FO3 Wanderers Edition - Main File.esm
[X] Mart's Mutant Mod.esm
[X] Companion Core.esm
[X] RobCo Certified v2.esm
[X] Enhanced Weather - Rain and Snow.esm
[X] Unofficial Fallout 3 Patch - Operation Anchorage.esp
[X] Unofficial Fallout 3 Patch - The Pitt.esp
[X] Unofficial Fallout 3 Patch - Broken Steel.esp
[X] Unofficial Fallout 3 Patch - Point Lookout.esp
[X] Unofficial Fallout 3 Patch - Mothership Zeta.esp
[X] Better Wasteland Clipboards.esp
[X] richvendors.esp
[X] OasisSafeWater.esp
[X] MS11fix.esp
[X] psychoelfs the family fix.esp
[X] FasterMorePowerfulMines.esp
[X] Rude Awakening.esp
[X] Rude Awakening - MMM.esp
[X] Project Beauty- Broken Steel.esp
[X] Project Beauty- Point Lookout.esp
[X] CRAFT - Activation Perk.esp
[X] DarNifiedUIF3.esp
[X] PreWar Book Titles and Perks.esp
[X] UPP - Pack 1.esp
[X] UPP - Pack 2.esp
[X] MTC Wasteland Travellers.esp
[X] MTC Wasteland Travellers (Optional)- Crowded Cities less NPCs.esp
[X] Megaton Tweaks - Snipers Edition.esp
[X] Revenge.esp
[X] Glow Sticks.esp
[X] Portable Tent.esp
[X] mazas_campfire.esp
[X] WW2Uniforms.esp
[X] Hard Disk Drives.esp
[X] 0rb_ComicPack1.esp
[X] sunglassescollection.esp
[X] Talon Outpost Expansion - Arlington.esp
[X] Talon Outpost Expansion - Rivet City.esp
[X] Talon Outpost Expansion - Canterbury Commons.esp
[X] Talon Outpost Expansion - Megaton.esp
[X] Talon Outpost Expansion - Takoma.esp
[X] Death Canyon v3.esp
[X] Ghoul Mansion v3.1.esp
[X] The Prisoners.esp
[X] Rat Trap v1.01.esp
[X] We Jazz.esp
[X] Existence2.0.esp
[X] PLMotelRoom1GImprovedVer.esp
[X] Point lookout new uniques.esp
[X] TinCanCRAFTing.esp
[X] Treasure Hunt!.esp
[X] NecronomiconExMortis 5.5.esp
[X] MegatonContracts.esp
[X] Devoured in Darkness.esp
[X] SecuredBarn.esp
[X] 01AtM - Firefly Ranch.esp
[X] UndergroundHideout.esp
[X] NotSoFast.esp
[X] HeirApparent.esp
[X] PLweightadjust.esp
[X] Treasure Maps_A Fist Full of Caps.esp
[X] Treasure Maps_Secrets of the Wasteland.esp
[X] Treasure Maps_Underground.esp
[X] sc_slaves_stick_around.esp
[X] sc_buying_slaves.esp
[X] EvilSlaves.esp
[X] Ghoulified Cromwell.esp
[X] MegatonScavengers.esp
[X] Raiders_gas_flamer.esp
[X] Not alone in the Wasteland anymore.esp
[X] FO3 Wanderers Edition - Main File.esp
[X] FO3 Wanderers Edition - DLC Anchorage.esp
[X] FO3 Wanderers Edition - DLC The Pitt.esp
[X] FO3 Wanderers Edition - DLC Broken Steel.esp
[X] FO3 Wanderers Edition - DLC Point Lookout.esp
[X] FO3 Wanderers Edition - DLC Mothership Zeta.esp
[X] FO3 Wanderers Edition - Followers Enhanced (BrokenSteel).esp
[X] FO3 Wanderers Edition - Optional VATS Realtime.esp
[X] FO3 Wanderers Edition - Optional Restore Tracers (automatics only).esp
[X] FO3 Wanderers Edition - Project Beauty.esp
[X] FO3 Wanderers Edition - Project Beauty (Followers Enhanced).esp
[X] FO3 Wanderers Edition - UFP Support.esp
[X] FO3 Wanderers Edition - Alternate Travel.esp
[X] FO3 Wanderers Edition - Optional Free Play After MQ.esp
[X] FO3 Wanderers Edition - Optional Worn Weapons.esp
[X] WeaponModKits.esp
[X] WeaponModKits - FWE Master Release.esp
[X] WeaponModKits - OperationAnchorage.esp
[X] WeaponModKits - FWE Optional Worn Weapons.esp
[X] WeaponModKits - ThePitt.esp
[X] WeaponModKits - BrokenSteel.esp
[X] WeaponModKits - PointLookout.esp
[X] WeaponModKits - Zeta.esp
[X] EVE.esp
[X] EVE Operation Anchorage.esp
[X] EVE - FWE Master Release.esp
[X] EVE Anchorage - FWE DLC Anchorage.esp
[X] EVE - FWE with WeaponModKits.esp
[X] EVE - FWE Master Release (Follower Enhanced).esp
[X] Mart's Mutant Mod.esp
[X] Mart's Mutant Mod - DLC Anchorage.esp
[X] Mart's Mutant Mod - DLC The Pitt.esp
[X] Mart's Mutant Mod - DLC Broken Steel.esp
[X] Mart's Mutant Mod - DLC Point Lookout.esp
[X] Mart's Mutant Mod - DLC Zeta.esp
[X] Mart's Mutant Mod - Project Beauty.esp
[X] Mart's Mutant Mod - FWE Master Release.esp
[X] Mart's Mutant Mod - Project Beauty + FWE.esp
[X] Banks of the Wasteland1-1.esp
[X] Owned!.esp
[X] Responsive Kill Reactions.esp
[X] xCALIBRmunitions.esp
[X] xCALIBRmunitions_FOSEnhancements.esp
[X] xCALIBR_override_FWE5.esp
[X] RobCo Certified v2 Zeta Addon.esp
[X] Companion Core DLC Addon.esp
[X] Enhanced Weather - Rain and Snow in Fallout.esp
[X] Enhanced Weather - Radioactive Rain and Snow Plugin.esp
[X] Enhanced Weather - Weather Sounds in Interiors.esp
[X] Enhanced Weather - Sneak Bonus during Storms.esp
[X] MergedPatch.esp

I'm confused, what is the problem exactly?

I think he doesn't want to see the start of the game anymore...

Isn't there an alternate start type option integrated into FWE?

Sorry I am just getting random frequent CTD. I have been messing with this load order and merged patch for 5 days now. I just wanted some expert to look at it and tell me if I have things correct or if there are any changes I should make. I just made ref to "James we did it" because I am hearing it in my sleep. Joke fell flat I guess.

try disabling:
[X] Megaton Tweaks - Snipers Edition.esp
see if that helps

Also, did you try using http://www.fallout3nexus.com/downloads/file.php?id=10193?

And you dont need/want this with broken steel [X] FO3 Wanderers Edition - Optional Free Play After MQ.esp

Thanks for the reply and tips. Yes I have tried Boss. All I get when I use it is a white page. I have it installed in the data folder under C:\Fo3\data. I have the correct runtime installed. Permissions on the folder are set.

Are you sure your launching BOSS from the batch file? On that one you dont want to launch it from the application file. Other than that, not sure why it's not working for you. Maybe someone else would know. Or you could ask on the BOSS thread or on nexus.

Yeah def launching bat. I posted a question about it in their thread.

Are you talking about the opening chargen scene when you're born? If that is where you are crashing, then do you have a quad core processor? What OS are you on? Answer these questions and I may be able to help you because I was unable to make it past the birth scene when I first bought this game but I fixed it.

The gentleman on the above posts helped quite a bit played for nearly 5 hours with no crash until I suddenly was unable to save my game without crashing. So now I gotta pin that down.

Thanks for the reply.Not crashing on start.I was just making a dumb joke about how many times I have listened to that phrase starting a new game. I figured it that phrase was floating around in the mind of a lot of people having problems. Yeah Vista 64 bit ultimate quad 4 gigs ram for the record.

On your computer, search for "msconfig", once the screen of msconfig opens, click on the "boot" tab, click advanced settings, click on the box next to "number of processors", then change the number to 2. Close the advanced settings menu, click "apply" on the msconfig menu, then hit "ok", then restart your computer. This will cause your computer to run with only 2 cores instead of 4, because fallout 3 was designed to be played with 2 cores and does not support 4.

When I got this game, I was freezing so much I couldn't get past the chargen, but after changing my computer to run on 2 cores it works perfectly and never freezes.

Also, if you wish to turn all 4 cores back on again to play newer games etc., then just go through the process mentioned above again, but uncheck the "number of processors" box, then apply, hit ok, restart computer.

What Sedhrw says, you probably don't have a multicore fix applied. You can do it the way he described or you can simply make a small change to the ini.
Save on crash is also a frequent problem and can be fixed by masterupdating your load order.

Check this http://sites.google.com/site/fo3wanderersedition/faq on how to fix the most common crash issues for Fallout 3.

If I may suggest, play all through the opening with no mods installed. The game automatically makes a save right at the exit. Keep a copy of this save somewhere and use it to start new games.

Thanks all for helpful comments. I applied the ram and multicore ini tweaks a while back. I saw a significant increase in fps after applying FO3 Ram booster and FOSE stutter fix.