Alright, so when I start the game, It CTD's. I used BOSS to sort my load order out already.


Fallout3.esm
Anchorage.esm
ThePitt.esm
BrokenSteel.esm
PointLookout.esm
Zeta.esm
Unofficial Fallout 3 Patch.esm
CRAFT.esm
CALIBR.esm
StreetLights.esm
FO3 Wanderers Edition - Main File.esm
Mart's Mutant Mod.esm
Enhanced Weather - Rain and Snow.esm
Project Beauty.esm
Unofficial Fallout 3 Patch - Operation Anchorage.esp
Unofficial Fallout 3 Patch - The Pitt.esp
Unofficial Fallout 3 Patch - Point Lookout.esp
Unofficial Fallout 3 Patch - Mothership Zeta.esp
Project Beauty- Broken Steel.esp
Project Beauty- Point Lookout.esp
DarNifiedUIF3.esp
Fellout-pipboylight.esp
CRAFT - Activation Perk.esp
SniperZooming.esp
Classic Fallout Weapons BETA.esp
UndergroundHideout.esp
FO3 Wanderers Edition - Main File.esp
FO3 Wanderers Edition - DLC Anchorage.esp
FO3 Wanderers Edition - DLC Broken Steel.esp
FO3 Wanderers Edition - DLC Mothership Zeta.esp
FO3 Wanderers Edition - DLC Point Lookout.esp
FO3 Wanderers Edition - DLC The Pitt.esp
FO3 Wanderers Edition - UFP Support.esp
FO3 Wanderers Edition - Followers Enhanced (BrokenSteel).esp
WeaponModKits.esp
WeaponModKits - FWE Master Release.esp
WeaponModKits - OperationAnchorage.esp
WeaponModKits - ThePitt.esp
WeaponModKits - BrokenSteel.esp
WeaponModKits - PointLookout.esp
WeaponModKits - Zeta.esp
WeaponModKits - FWE Optional Worn Weapons.esp
EVE.esp
EVE - FWE Master Release.esp
EVE - FWE Master Release (Follower Enhanced).esp
EVE Operation Anchorage.esp
EVE - FWE with WeaponModKits.esp
EVE Anchorage - FWE DLC Anchorage.esp
Mart's Mutant Mod.esp
Mart's Mutant Mod - DLC Anchorage.esp
Mart's Mutant Mod - DLC The Pitt.esp
Mart's Mutant Mod - DLC Broken Steel.esp
Mart's Mutant Mod - DLC Point Lookout.esp
Mart's Mutant Mod - DLC Zeta.esp
Mart's Mutant Mod - Hunting & Looting.esp
Mart's Mutant Mod - Natural Selection.esp
Mart's Mutant Mod - Tougher Traders.esp
Mart's Mutant Mod - FWE Master Release.esp
Enhanced Weather - Rain and Snow in Fallout.esp
Enhanced Weather - Sneak Bonus during Storms.esp
Fellout-Full.esp
Fellout-BrokenSteel.esp
Fellout-PointLookout.esp
Fellout-Zeta.esp
FO3 Wanderers Edition - Project Beauty (Followers Enhanced).esp
Mart's Mutant Mod - Project Beauty + FWE.esp
Mart's Mutant Mod - Project Beauty.esp
FO3 Wanderers Edition - Optional Restore Tracers (automatics only).esp
DUIF3Extras.esp

Total active plugins: 69
Total plugins: 69

If it's crashing when launching Fallout and before you even load or start a game, it's a missing master. Easiest way I can think is for FO3edit to do a merged patch and it'll tell you what's missing a master. Might be other ways

Hmm, I will download FO3 Edit and try this ASAP. Thank you for the fast response. I'll post results.

EDIT: Yeah, still a crash after the patch and here are my masters
Fallout3.esm
Anchorage.esm
ThePitt.esm
BrokenSteel.esm
PointLookout.esm
Zeta.esm
Unofficial Fallout 3 Patch.esm
FO3 Wanderers Edition - Main File.esm
Mart's Mutant Mod.esm
Project Beauty.esm
Classic Fallout Weapons BETA.esp
FO3 Wanderers Edition - DLC Anchorage.esp
FO3 Wanderers Edition - DLC Broken Steel.esp
WeaponModKits.esp
WeaponModKits - FWE Master Release.esp
WeaponModKits - OperationAnchorage.esp
WeaponModKits - ThePitt.esp
WeaponModKits - BrokenSteel.esp
WeaponModKits - PointLookout.esp
WeaponModKits - Zeta.esp
EVE.esp

Which version of DarNifiedUIF3 are you using? Latest version no longer requires DUIF3Extras.esp to be loaded. Also, which version of FOSE are you running? I don't see Unofficial Fallout 3 Patch - Broken Steel.esp in your list, now I'm not up-to-date with all those big mods you're using, so there may be a very good reason why you don't have that enabled. If you're not using UF3P - BS due to the Rivet City crash issue, then get the fixed version: http://www.google.co.uk/search?q=unofficial+fallout+3+patch+broken+steel+rc+and+utility+tunnel+fixes&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-GB:official&client=firefox-a B)

I didn't know UFP BS had a ctd on save issue.... ugh. That would probably explain my issues... Why isn't that fix on Nexus?

When using WMK, a merged patch created with FO3edit is obligatory as stated in the readme.
If you're using the last version of FWE, you don't need the optionnal plugins of MMM, as stated in the readme.
Also, Classic Fallout Weapons is integrated in FWE and DUIF3extra is not needed anymore as stated in the readme.

I would advise that you read all the reames of the mods you're trying to play with, that would save you a lot of frustration.
Also, look for a tutorial on FO3edit on FO3nexus, it will help you tremendously towards a stable game.

I would advise that you read all the reames of the mods you're trying to play with, that would save you a lot of frustration.
Also, look for a tutorial on FO3edit on FO3nexus, it will help you tremendously towards a stable game.
[/quote]

The FO3Masterupdate function cleared away a lot of problems for me, very easy to do. Anyhow here is a list of my very very stable load order I have played for 8 hours, dieing reloading, dieing reloading no crashes. Hope it helps.

[X] Fallout3.esm
[X] Anchorage.esm
[X] ThePitt.esm
[X] BrokenSteel.esm
[X] PointLookout.esm
[X] Zeta.esm
[X] Unofficial Fallout 3 Patch.esm
[X] CRAFT.esm
[X] CALIBR.esm
[X] xCALIBR.esm
[X] Project Beauty.esm
[X] SuperJump1.5x.esm
[X] The Bunker.esm
[X] COMM.esm
[X] FO3 Wanderers Edition - Main File.esm
[X] Mart's Mutant Mod.esm
[X] Companion Core.esm
[X] RobCo Certified v2.esm
[X] Enhanced Weather - Rain and Snow.esm
[X] DarNifiedUIF3.esp
[X] Unofficial Fallout 3 Patch - Operation Anchorage.esp
[X] Unofficial Fallout 3 Patch - The Pitt.esp
[X] Unofficial Fallout 3 Patch - Broken Steel.esp
[X] Unofficial Fallout 3 Patch - Point Lookout.esp
[X] Unofficial Fallout 3 Patch - Mothership Zeta.esp
[X] Project Beauty- Broken Steel.esp
[X] Project Beauty- Point Lookout.esp
[X] CRAFT - Activation Perk.esp
[X] TinCanCRAFTing.esp
[X] We Jazz.esp
[X] Existence2.0.esp
[X] Dree Perks.esp
[X] Dree Perks Anchorage.esp
[X] Dree Perks Point Lookout.esp
[X] Dree Perks Pitts.esp
[X] Dree Perks Mothership Zeta.esp
[X] Dree Perks Requested by Fans .esp
[X] Revenge.esp
[X] Glow Sticks.esp
[X] Portable Tent.esp
[X] WW2Uniforms.esp
[X] Hard Disk Drives.esp
[X] 0rb_ComicPack1.esp
[X] sunglassescollection.esp
[X] Point lookout new uniques.esp
[X] 01AtM - Firefly Ranch.esp
[X] UndergroundHideout.esp
[X] SecuredBarn.esp
[X] Ghoul Mansion v3.1.esp
[X] Death Canyon v3.esp
[X] Talon Outpost Expansion - Megaton.esp
[X] Talon Outpost Expansion - Rivet City.esp
[X] Talon Outpost Expansion - Arlington.esp
[X] Talon Outpost Expansion - Canterbury Commons.esp
[X] Talon Outpost Expansion - Takoma.esp
[X] NotSoFast.esp
[X] HeirApparent.esp
[X] PLweightadjust.esp
[X] The Prisoners.esp
[X] Rat Trap v1.01.esp
[X] Devoured in Darkness.esp
[X] PLMotelRoom1GImprovedVer.esp
[X] NecronomiconExMortis 5.5.esp
[X] MegatonContracts.esp
[X] Rude Awakening.esp
[X] Rude Awakening - MMM.esp
[X] Ghoulified Cromwell.esp
[X] MS11fix.esp
[X] psychoelfs the family fix.esp
[X] FasterMorePowerfulMines.esp
[X] PreWar Book Titles and Perks.esp
[X] Treasure Hunt!.esp
[X] Treasure Maps_A Fist Full of Caps.esp
[X] Treasure Maps_Secrets of the Wasteland.esp
[X] Treasure Maps_Underground.esp
[X] MegatonScavengers.esp
[X] littlefirestarters2.esp
[X] Raiders_gas_flamer.esp
[X] Not alone in the Wasteland anymore.esp
[X] RobCo Certified v2 Zeta Addon.esp
[X] Companion Core DLC Addon.esp
[X] FO3 Wanderers Edition - Main File.esp
[X] FO3 Wanderers Edition - DLC Anchorage.esp
[X] FO3 Wanderers Edition - DLC The Pitt.esp
[X] FO3 Wanderers Edition - DLC Broken Steel.esp
[X] FO3 Wanderers Edition - DLC Point Lookout.esp
[X] FO3 Wanderers Edition - DLC Mothership Zeta.esp
[X] FO3 Wanderers Edition - Followers Enhanced (BrokenSteel).esp
[X] FO3 Wanderers Edition - Optional VATS Realtime.esp
[X] FO3 Wanderers Edition - Optional Restore Tracers (automatics only).esp
[X] FO3 Wanderers Edition - UFP Support.esp
[X] FO3 Wanderers Edition - Alternate Travel.esp
[X] FO3 Wanderers Edition - Optional Worn Weapons.esp
[X] FO3 Wanderers Edition - Project Beauty.esp
[X] FO3 Wanderers Edition - Project Beauty (Followers Enhanced).esp
[X] WeaponModKits.esp
[X] WeaponModKits - FWE Master Release.esp
[X] WeaponModKits - FWE Optional Worn Weapons.esp
[X] WeaponModKits - OperationAnchorage.esp
[X] WeaponModKits - ThePitt.esp
[X] WeaponModKits - BrokenSteel.esp
[X] WeaponModKits - PointLookout.esp
[X] WeaponModKits - Zeta.esp
[X] EVE.esp
[X] EVE Operation Anchorage.esp
[X] EVE - FWE Master Release.esp
[X] EVE - FWE Master Release (Follower Enhanced).esp
[X] EVE Anchorage - FWE DLC Anchorage.esp
[X] EVE - FWE with WeaponModKits.esp
[X] MTC Wasteland Travellers.esp
[X] MTC Wasteland Travellers (Optional)- Crowded Cities less NPCs.esp
[X] Mart's Mutant Mod.esp
[X] Mart's Mutant Mod - DLC Anchorage.esp
[X] Mart's Mutant Mod - DLC The Pitt.esp
[X] Mart's Mutant Mod - DLC Broken Steel.esp
[X] Mart's Mutant Mod - DLC Point Lookout.esp
[X] Mart's Mutant Mod - DLC Zeta.esp
[X] Mart's Mutant Mod - Project Beauty.esp
[X] Mart's Mutant Mod - FWE Master Release.esp
[X] Mart's Mutant Mod - Project Beauty + FWE.esp
[X] Owned!.esp
[X] Better Wasteland Clipboards.esp
[X] EvilSlaves.esp
[X] richvendors.esp
[X] OasisSafeWater.esp
[X] Responsive Kill Reactions.esp
[X] xCALIBRmunitions.esp
[X] xCALIBRmunitions_FOSEnhancements.esp
[X] xCALIBR_override_FWE5.esp
[X] Enhanced Weather - Rain and Snow in Fallout.esp
[X] Enhanced Weather - Radioactive Rain and Snow Plugin.esp
[X] Enhanced Weather - Weather Sounds in Interiors.esp
[X] Enhanced Weather - Sneak Bonus during Storms.esp
[X] THE ROAD.esp
[X] MP.esp

I am not sure if the Road and Enchanced weather cancel eachother but I got a significant amount of FPS with Road installed.

cmcm777: What exactly is THE ROAD.esp? I searched nexus and all I found was roadwarrior files...

Not every time...
See http://www.gamesas.com/index.php?/topic/1095717-facepalm/ for a specific instance of a CTD at launch was not caused by a missing master.

In my situation, it was FWE and the Compatibility Patches (and, therefore, my MergedPatch) causing the CTDs.

Seems the updated FWE removes or changes a number of records that the CPs are looking for, so the CPs are nerfed.
If you want to run any mods with FWE that have CPs, you'll have to do so without any CPs. At least until the new CPs are made. Or else do some fancy tweaking, like I did ( :swear: :banghead: :flame: ).

In FOMM click 'check load order' or whatever it is and it'll give you a recommended list of how it should look, you should probably set it up how it says. When I had the CTD problem it happened right after I installed like 5 new mods, turns out it was one of the mods screwing up the game so I just uninstalled it and everything's better now. Probably your issue, too.