You know that you can limit yourself right, if you don't like fat mens, don't use em... If you find that VATS makes the game too easy for you, use it less or don't use it.
Most of the time I use VATS just for the cinematic experience, and then I won't use it awhile. Like using a minigun in VATS looks really cool but gamewise is pointless.
Na i never go to Anchorage until at least level 15-20. There was just so much ammo and so many of the fatman nuke guns around in the vanilla game it was kinda hard to see how the gun was supposed to be "powerful"