Do it without followers, or it's meaningless.
Yeah, I don't intend to take followers.
To me, it feels more like a survival game than a combat-RPG.
Also, especially since I'm playing with Fellout, which makes night time really, REALLY dark and Realistic Interior Lighting, which makes interiors pretty much black without a light source, things can get pretty tense. For example, I decided to check out the outside of Springvale school. At midnight. About 5 seconds later, I was running for my life back to Megaton with about 5% of my health, both legs and an arm crippled, being followed by 15 raiders. Once again, it didn't help that it was pretty much pitch black.
Traders are really bad, a half-repaired sniper rifle, my best weapon, only sells for 15 caps.
Warrington station was a NIGHTMARE. 50 ghouls. 1 Stealthboy. If I bump in to one, they all attack. How fun.
Also, for the first time EVER, I actually used a hotel.
EDIT: I actually highly recommend trying this, just for the experience. Not that it isn't fun.
EDIT 2: Oh god.... what am I going to do when I run in to Super Mutants?
EDIT 3: Or Deathclaws? And playing with MMM, there will be Matriarchs, too.... I'm scared.
I don't even want to think about facing a Gargantuan like this.