After struggling for weeks with this problem, I've finally decided to post a forum thread about my problem as I seem to have exhausted all Googleable solutions and still the problem persists.
Basically, my game can run wonderfully smoothly for ages at a time then - for seemingly no reason - it will have an annoying phase where I can't enter/exit *anywhere*, or save my game, without crashing to the desktop. I've removed all Fallout entries from FFDShow, tweaked a bunch of settings, closes all background apps, etc, etc - have even tried blowing myself up (which, strangely, does occasionally help). But the only solution that has actually proven to allow me to continue my game is to uncheck all my mods in FOMM {if any FOMM devs are reading this: please add a 'select/deselect all' button to the next release!}, load the game, enter the new area, save, exit, then load back with all the mods. However this is a major pain because I then lose all my Modded Weapons and Classic Fallout Weapons, and it is only a matter of time before the problem rears its ugly head again.
I'm going to type out my mod load order below. If anyone can provide any input into changes I should make, or even a mod I should consider removing, I would greatly appreciate your wisdom as I'm all out of ideas.
Fallout3.esm
Anchorage.esm
ThePitt.esm
Broken Steel.esm
PointLookout.esm
Zeta.esm
Unofficial Fallout 3 Patch.esm
Project Beauty.esm
Mart's Mutant Mod.esm
NoKarmaMsg.esp
Unofficial Fallout 3 Patch - Operation Anchorage.esp
Unofficial Fallout 3 Patch - The Pitt.esp
Unofficial Fallout 3 Patch - Broken Steel.esp
Unofficial Fallout 3 Patch - Point Lookout.esp
Unofficial Fallout 3 Patch - Mothership Zeta.esp
Project Beauty - Broken Steel.esp
Project Beauty - Point Lookout.esp
GalaxyNewsRadio100[M].esp
Classic Fallout Weapons BETA.esp
VATS Normal Weapon Degradation.esp
Tailor Maid.esp
Tailor Maid Anchorage.esp
Tailor Maid PITT.esp
Tailor Maid Brokensteel.esp
Tailor Maid ZETA.esp
Tailor Maid Black Retex.esp
WeaponModKits.esp
WeaponModKits - OperationAnchorage.esp
WeaponModKits - ThePitt.esp
WeaponModKits - Broken Steel.esp
WeaponModKits - PointLookout.esp
WeaponModKits - Zeta.esp
Nova Interaction Revised.esp
Karma-less Petty Crime.esp
PowerOfTheAtom.esp
FollowersRelax.esp
Ice Cold Nuka, Converted.esp
Mart's Mutant Mod.esp
Mart's Mutant Mod - DLC Anchorage.esp
Mart's Mutant Mod - DLC The Pitt.esp
Mart's Mutant Mod - DLC Broken Steel.esp
Mart's Mutant Mod - DLC Point Lookout.esp
Mart's Mutant Mod - DLC Zeta.esp
Mart's Mutant Mod - Feral Ghoul Rampage.esp
Mart's Mutant Mod - Hunting & Looting.esp
Mart's Mutant Mod - Increased Spawns.esp
Mart's Mutant Mod - Natural Selection.esp
Mart's Mutant Mod - Tougher Traders.esp
Mart's Mutant Mod - Zones Respawn.esp
Mart's Mutant Mod - Project Beauty.esp
danspatch.esp (My Merged Patch)