Give Puce Moose's mods a try. Beautiful quests that make you think; they don't hold your hand in the slightest, though. That said, Puce is pretty good at giving hints if you ask. http://www.fallout3nexus.com/modules/members/index.php?id=137055 should link to his Profile, where you can find all his mods (scroll down a bit). Have fun, and try not to die too often!
Puce Moose FTW! Really, they are better/funnier/more sophisticated than ANY vanilla-quest. Give it a try.
Maybe add http://www.fallout3nexus.com/downloads/file.php?id=6270 and http://www.fallout3nexus.com/downloads/file.php?id=8219 to the mix.
there's also some CPs for Return to Shady Sands and FWE/MMM.