Test in 20 them. Not 1000 poor civilians, that have no clue and are innocent and have to suffer. [censored] evil

20 is still too few to be statistically useful, especially when trying to determine the effect on a civilisation/large groups.

Yeah, its evil... But still, most of what the Alternative Univere's US did seemed to be.

Didn't you have to pay to get in the vault?
so if on a large scale science experiment were you had 3000-5000, ended up making you money, wouldnt that be the best experiment ever?

For certain values of "best"

Military experimentation on unknowing civilians goes back decades. There are many real instances of the US military conducting experiments on populations with drugs, radiation, etc, in the form of poisoning water supplies, giving them fake vaccines, etc. They also experimented on their own soldiers, both with and without their knowledge and consent. Look on Youtube for British soldiers on LSD. Quite hilarious, but a good example of military experimentation of hallucinagenics.

Obviously the Enclave lack the moral standard we expect (realistically or not) from today's politicians, businessmen and leaders. They're willing to murder anyone if they feel it suits their needs; if they felt it suited their needs to experiment on tens of thousands of civilians then they'd do it. Afterall, the Enclave's top priority was surviving post-apocalyptia in control. Experimenting with drugs on a large scale was obviously (to me, atleast theoretically) an experiment to test how viable it would be to drug large populations as a means of controlling them. What they needed was a large, self-sufficient community of people to subject to this experiment, making the Vault perfectly suitable. Afterall, someone would have noticed if they'd invaded some town, declared Marshal law, and started force-feeding people drugs before the war. Vaults serve the perfect large-scale population test location; they allow the Enclave the ability to control nearly every single variable in a scientific experimentation without any outside influence.

Oh, that reminds me.

Why didn't the Overseer of Vault 101 know who the Enclave were, or accept them?

If you return to Vault 101 during the Trouble on the Homefront quest and hack into the Overseer's computer (regardless if it is Mack or the original Overseer) it will mention that the Enclave initiated contact with Vault 101 and even gave legitimate communication codes, yet the Overseer decided not to allow them in. In the note the Overseer appears to not know who the Enclave is, nor does he trust them -- obviously he is not following the directives of the original Overseer, and infact seems to know nothing of them. Obviously he has been raised to adopt the value of keeping the Vault closed (as per initial instructions) but does so out morally, not through orders.

So.. what's

lol i watched that movie last night the reaver's are nuts ... 10% of the population survived but they went nuts!!!!

Because of the long amount of time and the damage to the infrastructure around the country since the Great War, most Vaults lost communication with the Enclave, or whatever part of the government they thought they were talking to. I believe this was said somewhere in the wiki, or the Fallout Bible. Anyway, the first Overseers of the Vaults received their instructions from Vault-Tec, and most Vaults did not know that they were being monitored at all. Even if Overseers from 101 had known about this fact in the past, it could be lost as easily as a file can accidentally be deleted from a computer, or an Overseer dying of illness before being able to tell his successor everything. Information breakdowns happen, especially over a 200 year period.