I have completed all the major quests and am now working to increase my levels in different areas so I'm basically roaming around and finding undiscovered caves and structures. It seems this problem occurred after I reached level 25 while in Shivering Isles. Whenever there is an autosave, the game and console would freeze. I went into options and de-selected all of the autosave features and everything seemed to work fine. However, when I attempt to do a manual save from the main menu, the game and console freeze again.
I have probably close to 60 Gb of free space on the drive, so there is plenty of room for new saves even if I didn't overwrite old ones. I've deleted some of my older saves, but it had no effect. It's only doing this with Oblivion and not any other games that I can detect.
Any ideas?