I am currently playing a high elf atronach that has armorer, blade, block, heavy armor, destuction, illusion and restoration as majors.
I am loving it. It is a melee/mage hybrid of course. I raised alchemy up to about 30 in the first level or two and make a lot of magicka restore potions. I enjoy my adventures running though the great forest hunting "Magic Mushrooms". I especially laugh about the time I did it naked for some reason (I think weight?)
Also fyi if you mix bog beacon caps with withering moon from SI you get a restore magicka and shield potion in one.
Oh, and btw I use a leveling mod so I don't need to hear anyone harping about putting all 3 endurance skills as majors. With the mod I use it doesn't matter.