Open up the .ini file located in My Documents>My Games>Fallout 3. *Do not alter the one in the actual game directory labeled Fallout_Default_ini*
In the FALLOUT.ini find the line
bUseThreadedAI=0
change the 0 to a 1
then below it add the line
iNumHWThreads=2
In the FALLOUT.ini find the line
bUseThreadedAI=0
change the 0 to a 1
then below it add the line
iNumHWThreads=2
EDIT: I was able to start the game by having it set to a smaller window rather then the full screen, but then the game crashed as soon as I was born.