The game started off so great! I didn't see a single bug for the first 15-20 hours. But when I got later in the game they came like crazy. I have not yet completed the game, because I am trying to do all lesser quests before the main one. But I can not complete these due to bugs. "SPOILERS" I hope you fix these bugs soon.

Oh my papa - Since I completed Melissas quest before I got thisone she has eighter despawned or died from the Deathclaws.
By a campfire on the trail - This quest actually just popped up when I walked past a fireplace. And it completed the objective about making healing powder, but nothing else happens or is written
Heartache by the Number - I had gotten her to agree to selling her caravan. But after I killed the shopkeepers for the Brotherhood, she said something about settling the score with the CCC lady and the quest turned into something different. Now I am stuck at "Find Alice McLafferty and settle accounts" But I cant talk to her about anything.
Wheel of Fortune - Can't talk to the guy in Nipton. He has nothing to say
ED-E My Love - Bringing him to the scrapyard and talking to the lady does nothing.

Theese are my current bugged quest. Quite alot I must say. Was hoping to shed a light on them so they can be solved soon.