Interacting with people in a normal manner? *gasp!* Can't have that, people must be able to get right to their quest objectives ASAP, no delay, hurry, hurry! No waste time chatting with people to find your target like a normal person, there's the target right there, go get 'im!
Lot of sarcasm on this thread, but whatever.
I won't turn on such "quest giver markers" (if they exist) until the end of the game, when I'm sifting through every bar and tavern looking for someone else to give me odd jobs.
I'm sure they didn't let you turn "quest destination markers" off and at the same time removed all other ways to find your destination. Would defeat the purpose.