I'm currently doing the The Wolf Queen Awakened quest. I manage to defeat her draugr minions and then when her blue spirit energy flies through the door on the other side of the room http://en.uesp.net/wiki/File:SR-quest-The_Wolf_Queen_Awakened.jpgand my game crashes back to desktop every single time. I've disabled all mods and still get this. This is my 2nd playthrough where this keeps happening. I'm not sure what's causing it.

I'm playing Skyrim LE on PC. Anyone come across this before and maybe know what the cause is? I couldn't find any information on UESP Wiki about this bug.

Yep, I got the same CTD over and over again no matter what I did. It's a known http://en.uesp.net/wiki/Skyrim:The_Wolf_Queen_Awakened#Bugs that should been fixed in the latest official patch, so make sure you're playing an updated Skyrim LE and use http://afkmods.iguanadons.net/index.php?/topic/4276-relzwipz-unofficial-skyrim-legendary-edition-patch-usleep/.

I didn't see the cause listed on the uesp page linked. If the outfit Potema shares with Elisif has been replaced, this will happen. I did that to myself a couple of times. What I never figured out was exactly why that did it, but now I only make the change after the quest is over.

I don't see the bug referenced on UESP Wiki? I have USLEEP 3.0.6 installed and I don't see a reference to the bug fix in the USLEEP 3.0.7 http://afkmods.iguanadons.net/Unofficial%20Skyrim%20Legendary%20Edition%20Patch%20Version%20History.html

Thanks for the tip. I'll check that out

Edit: Solved. Thank you Ghastley. That is what caused it. The CTD doesn't happen when I remove the mesh for that outfit from the Meshes folder.

If anyone can explain the mechanism that makes that crash the game, I'd like to know, just so I can avoid doing anything similar.

Bit of guesswork, but Potema's Remains is SkeletonRace, The YarlTorso03AA ArmorAddon used by the outfit ClothesJarl03 she shares with Elisif has skeletonrace set in additional races while most other clothing does not.

Perhaps this causes the problem, when her second version spawns with a modded item it should not be able to equip? Could run some tests tomorrow. I've got a save not to far from this quest.

Or perhaps, since these races use different skeletons, it is a rigging issue, don't know enough about that to test.

Edit:fixed some labeling

It fails if only the nif is replaced, i.e. Potema is still wearing YarlTorso03, but it's a modified mesh. Rigging is a possibility, if the modified mesh includes extra bones in its rigging. I''l have to compare the bones listed in the two nif's.