If you are going to install a mod like that, the best thing to do is read the mod description/readmefiles/userposts before you install the mod. Read them thoroughly. Even the user posts to get an idea of what other ppl are experiencing with it.
The author mentions multiple times the stress the mod can have on your system. He even alludes to the fact you can't really safely uninstall it mid game.
If after the above you are going to try the mod, you want to make a new manual save and THEN install it. Don't overwrite the manual save however.
You could also start a new game as well. You can always go back to the premodded save. Always a good idea to backup the saves folder in case something happens.