Hello everybody.
I used to have random and frequent CTD when i was playing Fallout 4 without specific reasons.
I remembered that i had the same problems during WoW Warlord of Draenor's beta.
My graphic card is a Geforce GTX 660 Ti which is overclocked by MSI.
I decided to use MSI Afterburner (NVidia Inspector or other tweaker should work too imo) and set base frequencies from NVidia specifications.
Since this modification, i have been able to play for 4 hours without any CTD.
Maybe it could help someone else.
(Sorry for my poor english, i'm french :/ )