I expect Beth to have a good idea and then not implemented them fully as an example
Stats/skills having an affect on dialog -good idea
The affect is just saying the same thing in a different way, no new info or quests or any tangible game effect so the less dedicated players don't miss out - Bad implementation
Combat maneuvers linked to skills - not a bad idea
Ballet dancing spinning, and other silliness - bad implementation
Thats the gist get a good idea and and a welcome addition to the game and then implemented it in a way that diminishes the effect making you think why bother?
More skill streamlining - although I don't see how they can do a lot they will find a way
Fallout style you can only attempt to picklooks, persuade etc, if your skill is high enough then it will lead to an awful mini game
This is a maybe, less weapons, one type of long blade, short blade, axe and blunt weapon, because really how many do we need?
The main quest will be straight forward, no paths no alternatives and it will be a do it now or we're all doomed (and that won't be the case while your off collecting 50 bunny ears for the fighters guild nothing will happen, and hardly any one will notice the dire peril)
No real politics the different factions/guilds will exist outside of each other I don't see this changing
They are not going to add in slews of RPG elements, first they don't want to turn off a new mainstream gamer who just wants to kill things "cos the talking is boring" and second a lot of gamers want all the achievements in one playthrough (never understood this personally I think achievements need to be optional or need to go)
There some of my predictions
Edit: oh and canon will be replaced and ignored for cool even if cool makes no sense and is a bad idea well its super cool so who cares, I would forgot about previous lore and just prey they don't butcher it as much as they did in FO3 and TES IV