Specs:
Intel Pentium B690 2.2GHz dual core, with Intel HD2000 IGP
8 GB RAM
Only mods I'm running are OOO and the OOO-compatible version of MMM. I have the graphics settings quite low.
I'm getting huge performance hits, especially when facing large groups of NPCs, regardless of whether they're visible on screen or obscured by a wall or something. Sometimes, though, it happens when I'm... not facing anything particularly demanding, like a stack of boxes.
My system runs New Vegas fine and I'm pretty sure that's a more system intensive version of the same engine.
Any ideas what might be going on?