I think destruction is a bad skill to perk for this experiment, because it's mostly viable until lvl 35 or 40.
Many people think illusion is overpowered, so that's a bad idea, too.
IMO, pickpocket, lock picking and speech are clear choices. Destruction might be the next "best", but only for its long term payoff. The last choice is tough, and it's more about a lack of synergy with the first four choices. Maybe restoration or alchemy, which might allow you to survive, but require a lot of maintenance effort.
The big perks to avoid are weapons, conjuration, smithing and enchant. You could maybe take one from weapons, smithing, or enchant, but any two of those would be too easy.
Edit: I forgot pickpocket, another clear winner. Oops. Are you playing master? My bet is that any build is viable on adept, and mostly viable on expert (except some bosses). Also, certain artifacts like the sanguine rose are game changers. SR by itself could get you through the majority of mid-level fights.
Yes, playing on Master. Currently level 10. So far, I've put perks into Lockpicking (x2), Pickpocket, Speech, Smithing, Alchemy, Enchanting (x2), and Illusion. I would have put more into Pickpocket and Speech instead of Illusion and Enchanting but I haven't used the skills enough to unlock new perks and I don't want to carry perks over to later levels. The main quest sort of forces you to spread out non-combat skill perks because there's little but combat and the occasional lock to pick. Now that I'm done with High Hrothgar and most of the Ivarstead quests I've gone back to Whiterun and spent some time selling loot, smithing, alchemy, enchantment, and picking locks. Have not been successful picking pockets yet.
Smithing has been the most useful skill so far, followed by Alchemy. Smithing provides a tangible benefit; Alchemy a small one. The enchantments I've gotten from Enchanting have been trivial. (1% less magicka to cast Conjuration!) Lockpicking perks really do seem pretty useless. Haven't been able to pickpocket yet, probably because I haven't put any perks into Sneak (though my Sneak score is decent). The trading benefit from Speech is pretty insignificant as well. With Lydia I can basically handle any ordinary foe, though with 100 Health and no weapon/armor perks I have to avoid getting hit, so I spend most of my time sniping, dodging, and using Destruction. Boss battles are a little tricky since they're all 1 hit kills on me. If I manage to get Oakflesh up before I get hit I sometimes survive the first hit (not to be underrated, since it effectively doubles my lifespan) but then I'm out of magicka (since I only have 100 points in it).
wrong chuck norris need no armor his beard is the hardest material in multiverse also he roundhouse kicks not punches he was forbidden by the gods from punching due to them feeling it when he did
I'm going to hunt down Chuck Norris and use his beard to make my next set of armor.
It isn't hard.
Imperial
Max out Speech, Lock pick, Pick Pocket, Illusion, Alteration, Block
Make sure to become a Vampire
Don't increase HP above 100
As for me, I just got a high level Breton character without using any perks so I can use whatever build I want to test out without making multiple characters for a 300ma, 400hp, 300sta type of build I'm going for.
I don't have any experience with vampires in this game. Why is becoming one bad?
Illusion can actually be very powerful and allow this build to make the game super easy even on Master.
I have Fury, but since the people I charm end up attacking me half the time anyway it's use is pretty unreliable.
hmm good idea 4 build i would say alchemy ive tried it not really useful for combat oriented speech not really that usefull just really makes u more money lockpicking is just timesaver restoration does have high point if u fight undead use the healing hands kills quickly so there is good benifts to that u said u were playing smart with build after those block because the skills just supplement what the shield does instead of actually adding better stuff pickpocket as no real big use considering all quest items can be stolen garunteed but after those ud really dont have choice other sneak or 2h if combined with the others
I have a feeling Beth has four basic builds in mind when it comes to handling enemies: Hulk (straight combat with combat/defensive perks); Harry Potter (straight magic); Batman (stealth/assassination/poison); and Iron Man (craft the best weapons and armor possible or craft cheap stuff and sell it to buy the stuff, enchant it, and buff up on potions before wading into battle). You're obviously not going into battle as a straight thief.
So far, this has been a challenging build on Master. The biggest liability is the 100 Health. I think if I put points there things would be easier. Putting all my points into Stamina doesn't do much since I can't really go toe to toe with enemies anyways. Lets me carry a little more loot, 'bout all.