Compared to Fallout 3 the distance at which you can visibly see your enemies (Even with a scope) is ridiculously short, making sniping nearly useless.
Another issue I've noticed is that anything that you can put a scope on severely lacks in the stopping power department with the exception of the Gauss rifle.
What happened to sniping deathclaws a mile away from the top of a USAF satellite?
also my .50 cal does less damage than my .44.