My problem occurs in one spot and one spot only - Brellach during the main Shivering Isles quest. After "Rebuilding the Gatekeeper" I went back to the palace and spoke to Sheogorath, he tasked me with the new quest and I left the palace (it autosaved) - I fast travelled to Camp Hopeful where it autosaved and then I went North to Brellach. I arrived and spoke to the Golden Saints and then tried to enter Brellach - the screen goes black and freezes (but I can hear the water) - no amount of waiting helps - it's locked up solid and it's time to hold the touch button on the front to reboot. So first I thought it was a glitch (I had been playing for a bit). So I reload the autosave and repeat exactly - same result. Now I figured I would see if I could determine the problem.
So I reload the autosave and try to manually save right away at Camp Hopeful - works fine. Start to head North, fight a couple of battles, shut down an Obelisk - try the manual save - works fine., As I approach Brellach I see the usually notation at the bottom "loading area" - I try to manually save after it disappears - nothing - frozen again. So now I think I'm hooped and will not be able to finish the Isles. So I do some reading and first try the remove game data - no changes (and by the way I can go anywhere else and play for a while and manually save - just not in the Brellach area). Next I learn about turning off the "autosave" so I do and BANG - it seems to work - I can enter Brellach now and move around - I tried to manually save and it froze - so I figured that I would go through it all, go back to the Palace and save there. So I reload - enter Brellach, complete the quest and walk back to the Palace - talk to Sheogorath, get tasked with the next part oft the quest, leave the Palace and try to manully save on the Palace grounds and it freezes. It seems now that once I enter the Brellach area - no more saves are possible - period. If I avoid the area - the game operates as you would expect.
This is frustrating and disappointing after all the time being put into it. Anyone have any ideas or help at all? the only other bad problem I had was that I lost my skeleton key on the Isles when I went to prison (the cave) and it wasn't with the rest of my gear in the chest - I thought it would be - so it's lost forever but I can live with that - but I wanted to finish the game and now it appears that I cannot.
Thanks.