Sometimes you just need to reduce your population but the only ways are to either rush a room repeatedly until the dweller dies from repeat failures or send a dweller to the wastes with no equipment, stims, or radaway and wait for them to die. Neither of those are very good methods. To that end, I suggest the following.
Banishment: You banish a dweller to the wasteland to never return, reducing your population by 1 for every dweller banished. Banishing a dweller does have the negative side effect of slightly lowering the happiness of other dwellers so be careful of banishing too many dwellers too quickly lest your vault fall in disarray.