K, lets start this.
Vault 101 was mostly tossed aside after 2 quests outside. Then Trouble on the Homefront happens where you return to the vault. Then Amata kicks you out for no single defined reason.
You can see what I'm getting at. I'm asking the modders to do a vault 101 quest line that deals with anything after the vault starts to go outside. Probably trading or raider attacks. Maybe a nice little war like the Enclave vs. Brotherhood at the end.