So...we know that our dog will be an essential character,i.e. it can't be killed.
What if in Fallout 4 we would be able to craft some kind of sticky explosives, will you attach it to your dog and send it at you enemies, and when if gets close - detonate it?
Will you send your dog in front of you in a building, to check is there is any mines or wire-triggered explosives?
Personally i wont even pick up a dog because i do not like followers, but for people who will - an immortal dog that we can give commands opens a wide range of possibilities.