Do any of you who still play Fallout 3 gimp your character in any major ways for the sake of a harder game or a game that creates a stronger connection with your character?

What is your weight limit/loot rules?
Quirks, habits, hobbies?
How many chems, ammo or other weightless items do you carry?
Any other interesting things you'd like to share, tips for roleplay or anything else that's related?