Only if the NPCs feel important and have meaningful personalities.
The romance options in Fable 2 would have been better left out, because all the NPCs felt shallow and lifeless.
Yes, Fable 2's NPC's were extremely shallow. (I did love playing the game co-op with my sister otherwise, though.) Mass Effect 2's NPC interactions would be nice. (I've been pretty spoiled by that game, lol!)
It's not on my wishlist, although I hope that the NPCs have more realistic relationships among themselves - including romantic ones (so, actually recognising their spouse and engaging with them differently than they would with other NPCs).
^This! If the Sims 2/3 games (which I've played many, many times) can do something as basic as that (acknowledging the existence of a spouse or pet, etc), then this game should something similar. =)