this is what was on fallout.wiki
"Saving inside the Overseer's office will result in a corrupted game save. Clear the Vault but do not enter the armory, unlock the armory from the Overseer's terminal, or save within the Overseer's office. You may go into the Overseer's office but can not save inside. The Armory is completely off limits until a patch resolves the problem. (Confirmed: once you use the Overseer's terminal. FATAL LOAD GLITCH)"
thats why i was wondering.
This hasn't happened to me. Been in there four times with different characters. I've been through alone, with companions, with V34 quest active, with V34 quest *not* active, and I've not had this happen to me.
I didn't save in the Overseer's Office though. When I go into Vault 34, it's like ripping off duct tape, or a band-aid -- do it fast and get it over with.