Yes this verry issue has been bouncing around my head for a while. Obviously the NPCs who are known for having a nuka cola collection would lose that if thier paraphernalia was replaced entirely at random. I figure that if vanilla Fallout had a hand placed weapon and ammo in the same place then odds are with Savage Wasteland the player would find one or the other but not both, so I wasn't worried to much about making all those items match. I had also considered using the misc junk items laying around and scripting karma checks to them. Good players may see the junk turn into Meds or Ammo, and Evil players might get Explosives or maybe Weapons. Thats just a vauge idea at this point and not anything I've been activley working on.
I'm not sure how to approach that. Meds into different meds, random junk into other random junk, but with a high chance of being the original item or not there I can see working well. Throwing karma into the mix would take more thought. It might be possible to throw karma in but let it play a very small part. Walking into the Megaton armory and then deciding to hang a "Medical Supply Closet" sign on the door would be wierd. However, getting in there and finding a few meds mixed in would make things interesting.
Here's an idea I just though of. Make it so that there are drawbacks and advantages based on your Karma. Good characters might have a higher chance to find medical supplies but weapons and ammo might be slightly more rare or perhaps make them "downgraded" weapons (like a pistol in place of an assault rifle). Teddy bears and toys might be more common with good karma, also "chems" like jet or psycho might be rarer. Evil karma might have a higher chance at ammo and explosives but healing meds would be rarer. You could add a higher chance for enhancing drugs in their place. Neutral players could fall somewhere in between.
Here are some examples
Assault Rifle...
Good: Lower chance of appearing. If it does it has a decent chance of being an assault rifle, but also a pretty good chance of being a 10mm pistol, .32 pistol, or hunting rifle
Neutral: Normal chance of appearing. Probably going to be the assault rifle, but it might be a hunting rifle or a combat shotgun.
Evil: Higher chance of appearing. If it does it has a good chance of being an assault rifle, but also a pretty good chance of being a combat shotgun, laser rifle, or even a sniper rifle.
Rad X...
Good: Higher chance of appearing. If it does it has a good chance to be Rad X, but also a pretty good chance of being Rad Away, Med-X, or a Stimpack
Neutral: Normal chance of appearing. Probably going to be Rad X, but might be Rad Away, Med-X, Jet, or Buffout
Evil: Lower chance of appearing. If it does it has a decent chance of being the Rad-X, but also a pretty good chance of being Jet, Buffout, or Pyscho
What are your thoughts on that?
EDIT: I do like the idea of random junk having a chance of being meds or ammo, but then it seems like you would be at an advantage for not being neutral. Although it would be more interesting if the neutral player had a greater chance of the junk being there. He might have fewer meds or ammo than a good or evil character, but he would have more crap to sell.