This really is the prime question isn't it.
For me, having weps with very low health wouldnt work so well. I have decreased the degradation to about 5% of stock as I found it stupidly unrealistic how fast guns wore out. I have upped the condition-jam rate though so that would cancel out the issue some extent, but that would leave my raiders defanged because of constantly jamming weapons.
As a possible solution to the weak gunless raiders, I would suggest 2 options.
First, Let them have guns that are dangerous but undesirable.
I have a .44 pipe rifle that does a lot of damage, but is very innaccurate and only single shot. Exactly the type of cheap, cobbled-together weapon raiders would be likely to have. Does a lot of damage, but definitely not the type of thing that a player is likely to collect. I think the sawed off also would fit this bill. Or even crossbows
Second, is to equip them with a more deadly set of melee weapons. I have ditched all the pool cues, switch blades and tire irons, and replaced them with a nasty assortment of axes, spiked maces, and machetes. They still suffer from a lack of ranged weps, but when they do get in close they are extremely dangerous.
If you are interested, I would be happy to let you have the weps I have banged together.
As for the question of Quantums and sugar bombs, I say strip em all. Its just silly that either would still be around, except in locked rooms and other special locations. I always thought both of those quests were a bit frivolous, and can definitly live without completing them.
A mod called "Savage Wasteland" should be savage, damn it!
It should leave you starving, scabby and half feral, not happily skipping about collecting soda and childrens cereal!